Do Observational Studies Agree With Randomized Trials?
نویسندگان
چکیده
منابع مشابه
Do observational studies using propensity score methods agree with randomized trials? A systematic comparison of studies on acute coronary syndromes.
AIMS Randomized controlled trials (RCTs) are the gold standard for assessing the efficacy of therapeutic interventions because randomization protects from biases inherent in observational studies. Propensity score (PS) methods, proposed as a potential solution to confounding of the treatment-outcome association, are widely used in observational studies of therapeutic interventions for acute cor...
متن کاملSystematic Review of Observational Studies With Validation in Randomized Trials
Structured summary 2 Provide a structured summary including, as applicable: background; objectives; data sources; study eligibility criteria,participants, and interventions; study appraisal and synthesis methods; results; limitations; conclusions andimplications of key findings; systematic review registration number.2
متن کاملObservational studies are complementary to randomized controlled trials.
Randomized controlled trials (RCTs) are considered the gold standard study design to investigate the effect of health interventions, including treatment. However, in some situations, it may be unnecessary, inappropriate, impossible, or inadequate to perform an RCT. In these special situations, well-designed observational studies, including cohort and case-control studies, may provide an alterna...
متن کاملObservational studies: going beyond the boundaries of randomized controlled trials.
The term observational study describes a wide range of study designs including prospective and retrospective cohort studies, case-control studies, and cross-sectional studies, a defining feature of which is that any intervention studied is determined by clinical practice and not the protocol. Data from large, prospective observational studies provide information about the safety and efficacy of...
متن کاملA comparison of observational studies and randomized, controlled trials
BACKGROUND For many years it has been claimed that observational studies find stronger treatment effects than randomized, controlled trials. We compared the results of observational studies with those of randomized, controlled trials. METHODS We searched the Abridged Index Medicus and Cochrane data bases to identify observational studies reported between 1985 and 1998 that compared two or mor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2020
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2019.12.007